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These include the nitric oxide (NO) signaling system, angiogenic responses via VEGFR2, and antioxidant defense mechanisms involving HO-1 and other key enzymes (Józwiak et al

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For instance, (Su(var)3-9, enhancer of zeste, Trithorax) domain-containing protein 7 (SETD7) and enhancer of zeste homolog 2 (EZH2) catalyze methylation at histone H3 lysine 4 (H3K4) and lysine 27 (H3K27), respectively (Sun et al., 2010